Human Chorionic Somatomammotropin (hCS) and Growth Hormone (hGH) during Pregnancy
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چکیده
منابع مشابه
Structure of genes for human growth hormone and chorionic somatomammotropin.
A 2.6-kilobase (kb) EcoRI restriction endonuclease fragment containing human growth hormone (hGH; somatotropin) gene sequences and a 2.8-kb EcoRI fragment containing human chorionic somatomammotropin (hCS; choriomammotropin) gene sequences have been identified by hybridization to cloned cDNA. Human DNA was cleaved with EcoRI and fractionated by preparative agarose gel electrophoresis; DNA in th...
متن کاملOvine chorionic somatomammotropin and foetal growth.
Ovine chorionic somatomammotropin (oCS) enhances the weight and bone growth of hypophysectomized rats. It acts as a bifunctional hormone, since it binds both to lactogenic and somatotropic receptors. Ovine foetus weight gain is closely related to oCS and oGH serum levels. oCS is able to stimulate somatomedins by foetal liver. Moreover, oCS specific receptors are present in some foetal tissues. ...
متن کاملDifferential expression of human placental growth-hormone variant and chorionic somatomammotropin in culture.
Regulation of human placental growth-hormone variant (hGH-V) in the presence of its own promoter has been studied. At term, 10-20% of placental mRNA is specific for chorionic somatomammotropin (hCS-A and -B) compared with 0.05% hGH-V, yet these genes show more than 90% sequence similarity at the nucleotide level. By using stable gene transfer of intact hGH-V and hCS-A genes into rat pituitary (...
متن کاملAntibodies to Human Growth Hormone (hgh) in Human Subjects Treated with Hgh.
Human growth hormone (HGH) (1, 2) has been used experimentally and therapeutically in man since 1957 (3-5). The metabolic and growth-promoting effects of the parenterally administered hormone in humans (3-5) and the antigenicity of various HGH preparations in rabbits and in guinea pigs (6, 7) are well documented. This paper describes the appearance of specific antibodiesto HGH in the plasma of ...
متن کاملMethionine oxidation in human growth hormone and human chorionic somatomammotropin. Effects on receptor binding and biological activities.
The oxidation of the methionine residues of human growth hormone (hGH) and human chorionic somatomammotropin (hCS) to methionine sulfoxide by hydrogen peroxide has been studied. The kinetics of oxidation of individual methionine residues has been measured by reverse-phase high pressure liquid chromatography tryptic peptide mapping. Met-170 is completely resistant to oxidation in both hormones. ...
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1974
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.50.6_987